Track-index-guided sustainable off-road operations using visual analytics, image intelligence and optimal delineation of track features

Visual-analytics-guided systems are replacing human efforts today. In many applications, movement in off-road terrain is required. Considering the need to negotiate various soft ground and desertic conditions, the beaten tracks of leading vehicles considered to be safe and suitable for guiding are used in such operations. During night, often, these tracks pass through low-contrast conditions posing difficulty in their identification. The maximization of track contrast is therefore desired. Many contrast enhancement techniques exist but their effectiveness varies as per the surrounding. Other than conventional techniques, the role of texture too becomes important for enhancing the differentiable track contrast. Gray-level co-occurrence matrix (GLCM)-based statistic measures are used here to evaluate the track texture. These measures are seen to improve the contrast of vehicle tracks significantly. A track-index-based technique is proposed to sort various images as per their effectiveness in increasing the track contrast. Different forms of track indices are proposed and compared. The proposed track index is seen as effective in sorting 88.8% of contrast images correctly. The proposed technique of creating and sorting images based on the contrast level is seen as a useful tool for improved fidelity in many difficult situations for making the off-road operations sustainable

Adaptive Technique for Contrast Enhancement of Leading Vehicle Tracks

During movement in various unpaved terrain conditions, the track impressions left over by the leading vehicles provide guiding and safe routes in the area. The delineation of these tracks captured by the images can extend immense support for guidance in real time. These tracks that look like edges in coarse-resolution images take the shape of elongated areas in fine-resolution images. In such a scenario, the high pass and edge detection filters give limited information to delineate these tracks passing through different surroundings. However, the distinct texture of these tracks assists in the delineation of these tracks from their surroundings. Gray level co-occurrence matrix (GLCM) representing the spatial relation of pixels is employed here to define the texture. The authors investigated the influence of different resolutions on the distinguishability of these tracks. The study revealed that texture plays an increasing role in distinguishing objects as the image resolution improves. The texture analysis extended to investigate the track impressions left over by the leading vehicle brings out an ample scope in delineating these tracks. The measures could improve the track contrast even better than conventional techniques. To select the most optimal contrast enhancement measure in a given scenario, authors proposed a quantified measure of track index. An investigation is made on the difference-based track index (TI) representing the mean contrast value of the track vis-à-vis off-track areas. The results show an increase in the quantified contrast from 7.83 per cent to 29.06 per cent. The proposed technique highlights the image with the highest track contrast in a given scenario. The study can lead to onboard decision-making for the rut following vehicles moving in low-contrast terrain

Indian consensus on durability of glycemic control in type 2 diabetes management and role of oral antidiabetic drugs

The prevalence of type 2 diabetes mellitus (T2DM) is increasing in an alarming way in India as well as across the globe. In order to minimize complications, there is a need to maintain good glycemic control in patients with T2DM and long-term durable glycemic control remains a challenge. Clinically, this challenge was addressed by step-wise intensification of therapy with additional antidiabetic drugs to maintain glycemic control. Various disease and patient-related factors as well as different antidiabetic agents influenced the durability of glycemic control differently. While understanding of the factors that influenced therapeutic outcomes had evolved, there was paucity of information about the durability of glycemic control and the role of oral antidiabetic drugs (OADs) in achieving it. With an objective to understand the role of durability of glycemic response in the management of Indian patients with T2DM, 4 advisory board meetings attended by 48 physicians from across the country were conducted in Mumbai, Delhi, Kolkata and Bengaluru. There was consensus to consider durability of glycemic control as an important goal in the management of T2DM. Personalized approach in T2DM management along with early initiation of dual combination therapy were recommended to achieve durability. Age group of patients, body mass index, glycated hemoglobin levels at diagnosis, presence or absence of comorbidities and complications are important factors that need to be considered before initiating dual combination therapy for patients with T2DM

3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial

Background: Liraglutide 3·0 mg was shown to reduce bodyweight and improve glucose metabolism after the 56-week period of this trial, one of four trials in the SCALE programme. In the 3-year assessment of the SCALE Obesity and Prediabetes trial we aimed to evaluate the proportion of individuals with prediabetes who were diagnosed with type 2 diabetes. Methods: In this randomised, double-blind, placebo-controlled trial, adults with prediabetes and a body-mass index of at least 30 kg/m2, or at least 27 kg/m2 with comorbidities, were randomised 2:1, using a telephone or web-based system, to once-daily subcutaneous liraglutide 3·0 mg or matched placebo, as an adjunct to a reduced-calorie diet and increased physical activity. Time to diabetes onset by 160 weeks was the primary outcome, evaluated in all randomised treated individuals with at least one post-baseline assessment. The trial was conducted at 191 clinical research sites in 27 countries and is registered with ClinicalTrials.gov, number NCT01272219. Findings: The study ran between June 1, 2011, and March 2, 2015. We randomly assigned 2254 patients to receive liraglutide (n=1505) or placebo (n=749). 1128 (50%) participants completed the study up to week 160, after withdrawal of 714 (47%) participants in the liraglutide group and 412 (55%) participants in the placebo group. By week 160, 26 (2%) of 1472 individuals in the liraglutide group versus 46 (6%) of 738 in the placebo group were diagnosed with diabetes while on treatment. The mean time from randomisation to diagnosis was 99 (SD 47) weeks for the 26 individuals in the liraglutide group versus 87 (47) weeks for the 46 individuals in the placebo group. Taking the different diagnosis frequencies between the treatment groups into account, the time to onset of diabetes over 160 weeks among all randomised individuals was 2·7 times longer with liraglutide than with placebo (95% CI 1·9 to 3·9, p<0·0001), corresponding with a hazard ratio of 0·21 (95% CI 0·13–0·34). Liraglutide induced greater weight loss than placebo at week 160 (–6·1 [SD 7·3] vs −1·9% [6·3]; estimated treatment difference −4·3%, 95% CI −4·9 to −3·7, p<0·0001). Serious adverse events were reported by 227 (15%) of 1501 randomised treated individuals in the liraglutide group versus 96 (13%) of 747 individuals in the placebo group. Interpretation: In this trial, we provide results for 3 years of treatment, with the limitation that withdrawn individuals were not followed up after discontinuation. Liraglutide 3·0 mg might provide health benefits in terms of reduced risk of diabetes in individuals with obesity and prediabetes. Funding: Novo Nordisk, Denmark

Sodium-glucose cotransporter-2 inhibitors in combination with other glucose-lowering agents for the treatment of type 2 diabetes mellitus

Involvement of multiple physiological pathways and complex pathogenesis is responsible for the onset and progression of type 2 diabetes mellitus (T2DM). Since it is difficult to manage multiple pathophysiological defects by monotherapy, a combination therapy with two or more oral antidiabetic agents (OADs) may help achieve euglycemia in T2DM patients. Choice of OADs is difficult with growing armamentarium of antidiabetic therapy. Ideally, drug combination should aim at reversal of known pathogenic abnormalities and demonstrate improvement in the overall metabolic health rather than simply reduce glycosylated hemoglobin (HbA1c) levels. Increased glucose reabsorption, a faulty pathological mechanism, is targeted by a novel class of drugs, namely, the sodium-glucose cotransporter-2 (SGLT2) inhibitors. Combination of SGLT2 inhibitors and other OADs complement each other due to their unique mechanism of action. In addition, the glucose-lowering effect of SGLT2 inhibitors remains independent of β-cell function and insulin sensitivity which reduces the chances of severe hypoglycemia in patients receiving these agents. Clinical studies from the past favor the use of SGLT2 inhibitors in combination with other agents to achieve better HbA1c levels, weight loss, and blood pressure control. In this review, we have made an attempt to explore the recommended guidelines for combination therapy, its advantages as either combination therapy or fixed-dose combinations therapy, and the role of SGLT2 inhibitors as a choice of drug as a combination with other OADs

Efficient ring opening of aziridines with carboxylic acids

An efficient ring cleavage of aziridines with acids has been studied in the absence of any catalyst. The hydrolysis of the products, amino esters, leads to the corresponding amino alcohols. The reaction has been extended to chiral cycloalkyl aziridines, leading to the formation of diastereomers. After separation, these diastereomers have been converted to optically pure amino alcohols in two steps

Assessing vulnerability of forest ecosystem in the Indian Western Himalayan region using trends of net primary productivity

The Himalayan ecosystem is one of the sensitive and fragile ecosystems with rich biodiversity that provides major ecosystem services. The study was conducted to measure the extent of vulnerability across forested grids of Uttarakhandone of the States of Indian Western Himalayan (IWH) region. The forests of the state are exposed to various anthropogenic and natural climatic pressures, thus making them vulnerable. In this paper, we demonstrate how to map vulnerability of forest ecosystem by analyzing variability and trends of net primary productivity (NPP). The vulnerability of the forest ecosystem was evaluated through trends of sensitivity and adaptability of NPP. The sensitivity of a system was considered as the response degree of the system to climatic variability whereas adaptability was considered as the ability to maintain, recover or improve its structure in the face of climatic stresses. In our study, NPP was considered as the receptor of shock and stresses of climatic variability and human disturbances. We discuss the method and results with reference to productivity changes under the influence of changing climate for the forested landscape of a mountainous region. The results have been summarized to rank vulnerability at the level of administrative boundary of governance, i.e. district. Average value of vulnerability for all NPP pixels of forests grids in a district was used to compute the vulnerability at district level. The study will help forest managers in decision making for efficiently allocating resources and to prioritize management options in the identified regions to improve productivity in coming times

PhenoPine: A simulation model to trace the phenological changes in Pinus roxhburghii in response to ambient temperature rise

The PhenoPine is a Growing Degree Day (GDD) simulation model that can be used to trace the phenology of pine (Pinus roxburghii) under changing regimes of ambient temperature rise. The PhenoPine was developed using field-based observations for pine - a dominant tree species under the ``Chir Pine forests'' of Indian Western Himalayan region. Phenological stages of pine have been worked out on the basis of GDD. The GDD was computed assuming zero degree Celsius as base temperature and the accumulated averaged values over different phenological stages for developing phenology of the tree. The model has been built in Fortran Simulation Translator. Initially, the model has been developed to trace the impacts of temperature considering temperature as the major driving force for the phenology, while the lack of data for other forces also made this an obvious choice. Simulation through the PhenoPine can be done to trace the stages of initiation and termination of needle (leaf) formation, litter fall, cone formation; and the longevity of each phases under the changing regime of temperature rise

Type 1 diabetes: awareness, management and challenges: current scenario in India

Type 1 Diabetes Mellitus (T1DM) has a wide presence in children and has a high mortality rates. The disease, if left unmanaged, poses various challenges to the patient and healthcare providers, including development of diabetic complications and thus decreasing the life expectancy of the affected child. The challenges of T1DM include awareness of the disease that is very poor among the general public and also in parents of T1DM children along with the health care professionals. The challenge of lack of awareness of T1DM can be met by increasing public awareness programs, conducting workshops for diabetes educators regarding T1DM in children, newsletters, CMEs, online courses, and by structured teaching modules for diabetes educators. Diagnosis of T1DM was a challenge a few decades ago but the situation has improved today with diagnostic tests and facilities, made available even in villages. Investigation facilities and infrastructure, however, are very poor at the primary care level, especially in rural areas. Insulin availability, acceptability, and affordability are also major problems, compounded by the various types of insulin that are available in the market with a varied price range. But effective use of insulin remains a matter of utmost importance.e courses, and by structured teaching modules for diabetes educators. Diagnosis of T1DM was a challenge a few decades ago but the situation has improved today with diagnostic tests and facilities, made available even in villages. Investigation facilities and infrastructure, however, are very poor at the primary care level, especially in rural areas. Insulin availability, acceptability, and affordability are also major problems, compounded by the various types of insulin that are available in the market with a varied price range. But effective use of insulin remains a matter of utmost importance

Addendum: First injection technique recommendations for patients with diabetes, Forum for Injection Techniques India

The forum for injection techniques, India recommendation, the first ever in the country on insulin injcetion techniques, have covered the science and the art of insulin injection technique in an exhaustive manner. However, a few gaps were identified in the document, which are addressed in the current addendum. This article focuses on insulin injection technique in special clinical situations, including geriatric people, women in pregnancy and those with dermatological or surgical disease who live with diabetes. The addendum also covers salient features of administration of insulin using the insulin pump